8b7b: Difference between revisions

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-'''Unreleased structure'''
-The entry 8b7b is ON HOLD  until Paper Publication
+==Tubulin - maytansinoid - 6 complex==
+<StructureSection load='8b7b' size='340' side='right'caption='[[8b7b]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8b7b]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B7B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B7B FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PX0:(~{Z})-11-[[(1~{R},2~{R},3~{S},5~{S},6~{S},16~{E},18~{E},20~{R},21~{S})-11-chloranyl-12,20-dimethoxy-2,5,9,16-tetramethyl-21-oxidanyl-8,23-bis(oxidanylidene)-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1^{10,14}.0^{3,5}]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy]-11-oxidanylidene-undec-2-enoic+acid'>PX0</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b7b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b7b OCA], [https://pdbe.org/8b7b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b7b RCSB], [https://www.ebi.ac.uk/pdbsum/8b7b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b7b ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Maytansinoids are a successful class of natural and semisynthetic tubulin binders, known for their potent cytotoxic activity. Their wider application as cytotoxins and chemical probes to study tubulin dynamics has been held back by the complexity of natural product chemistry. Here we report the synthesis of long-chain derivatives and maytansinoid conjugates. We confirmed that bulky substituents do not impact their high activity or the scaffold's binding mode. These encouraging results open new avenues for the design of new maytansine-based probes.
-Authors:
+Maytansinol Functionalization: Towards Useful Probes for Studying Microtubule Dynamics.,Boiarska Z, Perez-Pena H, Abel AC, Marzullo P, Alvarez-Bernad B, Bonato F, Santini B, Horvath D, Lucena-Agell D, Vasile F, Sironi M, Diaz JF, Prota AE, Pieraccini S, Passarella D Chemistry. 2023 Jan 24;29(5):e202203431. doi: 10.1002/chem.202203431. Epub 2022 , Dec 30. PMID:36468686<ref>PMID:36468686</ref>
-Description:
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 8b7b" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bos taurus]]
+[[Category: Gallus gallus]]
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Abel A-C]]
+[[Category: Alvarez-Bernad B]]
+[[Category: Boiarska Z]]
+[[Category: Bonato F]]
+[[Category: Diaz JF]]
+[[Category: Horvath D]]
+[[Category: Lucena-Agell D]]
+[[Category: Marzullo P]]
+[[Category: Passarella D]]
+[[Category: Perez-Pena H]]
+[[Category: Pieraccini S]]
+[[Category: Prota AE]]
+[[Category: Santini B]]
+[[Category: Sironi M]]
+[[Category: Steinmetz MO]]
+[[Category: Vasile F]]