JMS/sandbox15: Difference between revisions
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Another way to say this, in the case of proteins <scene name='57/575026/Electrostatics/16'>in solvents such as water</scene>, is that, for each and every protein, <scene name='57/575026/Electrostatics/24'>water binds to the hydrogens</scene> (e.g., lysine's ammonium at physiology pH has three hydrogens - not shown) coming off a positively charged atom, or associates with the charged atom itself, thus screening each protein from the other proteins. | Another way to say this, in the case of proteins <scene name='57/575026/Electrostatics/16'>in solvents such as water</scene>, is that, for each and every protein, <scene name='57/575026/Electrostatics/24'>water binds to the hydrogens</scene> (e.g., lysine's ammonium at physiology pH has three hydrogens - not shown) coming off a positively charged atom, or associates with the charged atom itself, thus screening each protein from the other proteins. | ||
Still, this picture is incomplete. While illustrative of the basic principles of how small electrostatic fields changes can greatly increase a protein's solubility, there other contributing factors to the electrostatic field, e.g., solvated ions, crowding conditions, and the neighboring residues to these divergent residues. For example, when a negatively charged residue neigbors one of these additional positive residues, then from a distance relatively larger than the distance between the two oppositely charged residues, the electrostatic field is zero. | Still, this picture is incomplete. While illustrative of the basic principles of how small electrostatic fields changes can greatly increase a protein's solubility, there other contributing factors to the electrostatic field, e.g., solvated ions, crowding conditions, and the neighboring residues to these divergent residues. For example, when a negatively charged residue neigbors one of these additional positive residues, then from a distance relatively larger than the distance between the two oppositely charged residues, the electrostatic field is zero<ref>https://pdb101.rcsb.org/motm/1#:~:text=PDB%2D101%3A%20Molecule%20of%20the%20Month%3A%20Myoglobin.</ref> | ||
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