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==Folding Intermediate of the Fyn SH3 A39V/N53P/V55L from NMR Relaxation Dispersion Experiments==
==Folding Intermediate of the Fyn SH3 A39V/N53P/V55L from NMR Relaxation Dispersion Experiments==
<StructureSection load='2l2p' size='340' side='right'caption='[[2l2p]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2l2p' size='340' side='right'caption='[[2l2p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2P FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l2p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2P FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1shf|1shf]], [[3cqt|3cqt]], [[2lp5|2lp5]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FYN ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2p OCA], [https://pdbe.org/2l2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2p RCSB], [https://www.ebi.ac.uk/pdbsum/2l2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2p OCA], [https://pdbe.org/2l2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2p RCSB], [https://www.ebi.ac.uk/pdbsum/2l2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/FYN_CHICK FYN_CHICK]] Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.<ref>PMID:7496631</ref>
[https://www.uniprot.org/uniprot/FYN_CHICK FYN_CHICK] Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling.<ref>PMID:7496631</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Cavalli A]]
[[Category: Cavalli, A]]
[[Category: Kay LE]]
[[Category: Kay, L E]]
[[Category: Neudecker P]]
[[Category: Neudecker, P]]
[[Category: Robustelli P]]
[[Category: Robustelli, P]]
[[Category: Vendruscolo M]]
[[Category: Vendruscolo, M]]
[[Category: Amyloid fibril]]
[[Category: Chemical exchange]]
[[Category: Cpmg nmr relaxation dispersion]]
[[Category: Fyn sh3 domain]]
[[Category: Protein folding intermediate]]
[[Category: Transferase]]

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