8ov6: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8ov6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OV6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[8ov6]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OV6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U79:methyl+2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate'>U79</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.77Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U79:methyl+2-[(9~{S})-7-[4-[4-[[4-[(3-cyano-4-methyl-1~{H}-indol-7-yl)sulfamoyl]phenyl]methylcarbamoyl]phenyl]phenyl]-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoate'>U79</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ov6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ov6 OCA], [https://pdbe.org/8ov6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ov6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ov6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ov6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ov6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ov6 OCA], [https://pdbe.org/8ov6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ov6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ov6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ov6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 13:18, 16 August 2023
Ternary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPBTernary structure of bivalent glue degrader compound 1 bound to BRD4 and DCAF16:DDB1deltaBPB
Structural highlights
FunctionDCA16_HUMAN Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.[1] [2] References
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