1nde: Difference between revisions

<table><tr><td colspan='2'>[[1nde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NDE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NDE FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MON:4-(2-{[4-{[3-(4-CHLOROPHENYL)PROPYL]SULFANYL}-6-(1-PIPERAZINYL)-1,3,5-TRIAZIN-2-YL]AMINO}ETHYL)PHENOL'>MON</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ESTRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nde FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nde OCA], [http://pdbe.org/1nde PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nde RCSB], [http://www.ebi.ac.uk/pdbsum/1nde PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nde ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN]] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.  

[[Category: Human]]

[[Category: Consler, T G]]

[[Category: Go, N]]

[[Category: Hale, R L]]

[[Category: Henke, B R]]

[[Category: Hohman, D R]]

[[Category: Jones, S A]]

[[Category: Lambert, M H]]

[[Category: Lu, A T]]

[[Category: Moore, J T]]

[[Category: Moore, L B]]

[[Category: Orband-Miller, L A]]

[[Category: Robinett, R G]]

[[Category: Shearin, J]]

[[Category: Spearing, P K]]

[[Category: Stewart, E L]]

[[Category: Turnbull, P S]]

[[Category: Weaver, S L]]

[[Category: Williams, S P]]

[[Category: Wisely, G B]]

[[Category: Triazine]]