1jln: Difference between revisions
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<StructureSection load='1jln' size='340' side='right'caption='[[1jln]], [[Resolution|resolution]] 1.81Å' scene=''> | <StructureSection load='1jln' size='340' side='right'caption='[[1jln]], [[Resolution|resolution]] 1.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jln]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1jln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLN FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jln OCA], [https://pdbe.org/1jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jln RCSB], [https://www.ebi.ac.uk/pdbsum/1jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jln ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PTPRR_MOUSE PTPRR_MOUSE] Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.<ref>PMID:10949045</ref> <ref>PMID:10601328</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Aricescu AR]] | |||
[[Category: Aricescu | [[Category: Fulga TA]] | ||
[[Category: Fulga | [[Category: Renault L]] | ||
[[Category: Renault | [[Category: Scheidig AJ]] | ||
[[Category: Scheidig | [[Category: Szedlacsek SE]] | ||
[[Category: Szedlacsek | |||