1jln: Difference between revisions

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<StructureSection load='1jln' size='340' side='right'caption='[[1jln]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='1jln' size='340' side='right'caption='[[1jln]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1jln]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1JLN FirstGlance]. <br>
<table><tr><td colspan='2'>[[1jln]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLN FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jln OCA], [http://pdbe.org/1jln PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jln RCSB], [http://www.ebi.ac.uk/pdbsum/1jln PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jln ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jln FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jln OCA], [https://pdbe.org/1jln PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jln RCSB], [https://www.ebi.ac.uk/pdbsum/1jln PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jln ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PTPRR_MOUSE PTPRR_MOUSE]] Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.<ref>PMID:10949045</ref> <ref>PMID:10601328</ref>
[https://www.uniprot.org/uniprot/PTPRR_MOUSE PTPRR_MOUSE] Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.<ref>PMID:10949045</ref> <ref>PMID:10601328</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Aricescu AR]]
[[Category: Aricescu, A R]]
[[Category: Fulga TA]]
[[Category: Fulga, T A]]
[[Category: Renault L]]
[[Category: Renault, L]]
[[Category: Scheidig AJ]]
[[Category: Scheidig, A J]]
[[Category: Szedlacsek SE]]
[[Category: Szedlacsek, S E]]
[[Category: Erk2-map kinase regulation]]
[[Category: Hydrolase]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Ptp-sl]]
[[Category: Ptpbr7]]

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