1jbw: Difference between revisions
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<StructureSection load='1jbw' size='340' side='right'caption='[[1jbw]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='1jbw' size='340' side='right'caption='[[1jbw]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1jbw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBW FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACQ:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACQ</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TMF:5,10-METHYLENE-6-HYDROFOLIC+ACID'>TMF</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbw OCA], [https://pdbe.org/1jbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbw RCSB], [https://www.ebi.ac.uk/pdbsum/1jbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbw OCA], [https://pdbe.org/1jbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbw RCSB], [https://www.ebi.ac.uk/pdbsum/1jbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FPGS_LACCA FPGS_LACCA] Involved in the conversion of folates to polyglutamate derivatives, and likely functions in the retention of cellular folate pools. Catalyzes successive MgATP-dependent additions of glutamate to a pteroylmonoglutamate substrate, with a high preference for 5,10-methylenetetrahydrofolate (mTHF). Thus, metabolizes mTHF to the tetraglutamate derivative, but longer glutamate chain length products are not observed. Tetrahydrofolate (H4PteGlu) and 10-formyl-H4PteGlu are poorer folate substrates. In contrast to E.coli FolC, this enzyme does not display dihydrofolate synthase activity.<ref>PMID:18232714</ref> <ref>PMID:6138353</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Lacticaseibacillus casei]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Baker EN]] | |||
[[Category: Baker | [[Category: Bognar AL]] | ||
[[Category: Bognar | [[Category: Cross JA]] | ||
[[Category: Cross | [[Category: Smith CA]] | ||
[[Category: Smith | [[Category: Sun X]] | ||
[[Category: Sun | |||