5he4: Difference between revisions

<table><tr><td colspan='2'>[[5he4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HE4 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=60T:(2E,4AR,7AS)-7A-(2,6-DIFLUOROPHENYL)-6-(5-FLUORO-4-METHOXY-6-METHYLPYRIMIDIN-2-YL)-2-IMINO-3-METHYLOCTAHYDRO-4H-PYRROLO[3,4-D]PYRIMIDIN-4-ONE'>60T</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5he4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5he4 OCA], [https://pdbe.org/5he4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5he4 RCSB], [https://www.ebi.ac.uk/pdbsum/5he4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5he4 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  

[[Category: Homo sapiens]]

[[Category: Orth P]]