2hlc: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HLC FirstGlance]. <br> | <table><tr><td colspan='2'>[[2hlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HLC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlc OCA], [https://pdbe.org/2hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hlc RCSB], [https://www.ebi.ac.uk/pdbsum/2hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hlc ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hlc OCA], [https://pdbe.org/2hlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hlc RCSB], [https://www.ebi.ac.uk/pdbsum/2hlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hlc ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/COGS_HYPLI COGS_HYPLI] This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-|-Try-16 and 22-Arg-|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.<ref>PMID:230030</ref> <ref>PMID:2995028</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Hypoderma lineatum]] | [[Category: Hypoderma lineatum]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arnoux | [[Category: Arnoux B]] | ||
[[Category: Broutin | [[Category: Broutin I]] | ||
[[Category: Ducruix | [[Category: Ducruix A]] | ||
[[Category: Merigeau | [[Category: Merigeau K]] | ||