8imz: Difference between revisions
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==Cryo-EM structure of mouse Piezo1-MDFIC complex (composite map)== | |||
<StructureSection load='8imz' size='340' side='right'caption='[[8imz]], [[Resolution|resolution]] 3.66Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8imz]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IMZ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.66Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8imz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8imz OCA], [https://pdbe.org/8imz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8imz RCSB], [https://www.ebi.ac.uk/pdbsum/8imz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8imz ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Bavi N]] | |||
[[Category: Cheng D]] | |||
[[Category: Corry B]] | |||
[[Category: Cox CD]] | |||
[[Category: Harvey N]] | |||
[[Category: Li JV]] | |||
[[Category: Lin Y]] | |||
[[Category: Ma X]] | |||
[[Category: Sutton D]] | |||
[[Category: Yao M]] | |||
[[Category: Zhang Y]] | |||
[[Category: Zhou Z]] | |||