5gsl: Difference between revisions

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<StructureSection load='5gsl' size='340' side='right'caption='[[5gsl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5gsl' size='340' side='right'caption='[[5gsl]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5gsl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GSL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5gsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GSL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gsm|5gsm]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH0511 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gsl OCA], [https://pdbe.org/5gsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gsl RCSB], [https://www.ebi.ac.uk/pdbsum/5gsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gsl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gsl OCA], [http://pdbe.org/5gsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gsl RCSB], [http://www.ebi.ac.uk/pdbsum/5gsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gsl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLMA_PYRHO GLMA_PYRHO] Exo-type enzyme that specifically cleaves the non-reducing terminal glycosidic bond of chitooligosaccharides (PubMed:16912928, PubMed:28130448). Catalyzes the hydrolysis of GlcN-GlcNAc to glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) (PubMed:28130448). Involved in chitin degradation (PubMed:16912928). Can also hydrolyze chitosan and chitooligosaccharides of various chain lengths (PubMed:16912928).<ref>PMID:16912928</ref> <ref>PMID:28130448</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: Kamachi, S]]
[[Category: Kamachi S]]
[[Category: Mine, S]]
[[Category: Mine S]]
[[Category: Watanabe, M]]
[[Category: Watanabe M]]
[[Category: Glycoside hydrolase tim-barrel]]
[[Category: Hydrolase]]

Latest revision as of 14:41, 2 August 2023

Glycoside hydrolase AGlycoside hydrolase A

Structural highlights

5gsl is a 2 chain structure with sequence from Pyrococcus horikoshii OT3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLMA_PYRHO Exo-type enzyme that specifically cleaves the non-reducing terminal glycosidic bond of chitooligosaccharides (PubMed:16912928, PubMed:28130448). Catalyzes the hydrolysis of GlcN-GlcNAc to glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) (PubMed:28130448). Involved in chitin degradation (PubMed:16912928). Can also hydrolyze chitosan and chitooligosaccharides of various chain lengths (PubMed:16912928).[1] [2]

References

  1. ↑ Liu B, Li Z, Hong Y, Ni J, Sheng D, Shen Y. Cloning, expression and characterization of a thermostable exo-beta-D-glucosaminidase from the hyperthermophilic archaeon Pyrococcus horikoshii. Biotechnol Lett. 2006 Oct;28(20):1655-60. PMID:16912928 doi:10.1007/s10529-006-9137-0
  2. ↑ Mine S, Watanabe M, Kamachi S, Abe Y, Ueda T. The Structure of an Archaeal β-Glucosaminidase Provides Insight into Glycoside Hydrolase Evolution. J Biol Chem. 2017 Mar 24;292(12):4996-5006. PMID:28130448 doi:10.1074/jbc.M116.766535

5gsl, resolution 2.60Å

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