5ggb: Difference between revisions

No edit summary
No edit summary
 
Line 3: Line 3:
<StructureSection load='5ggb' size='340' side='right'caption='[[5ggb]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
<StructureSection load='5ggb' size='340' side='right'caption='[[5ggb]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ggb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GGB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GGB FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ggb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GGB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8GD:2-DEOXY-8-OXOGUANOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>8GD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gg5|5gg5]], [[5gg6|5gg6]], [[5gg7|5gg7]], [[5gg8|5gg8]], [[5gg9|5gg9]], [[5gga|5gga]], [[5ggc|5ggc]], [[5ggd|5ggd]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8GD:2-DEOXY-8-OXOGUANOSINE+5-(TRIHYDROGEN+DIPHOSPHATE)'>8GD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MSMEG_2390 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ggb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ggb OCA], [https://pdbe.org/5ggb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ggb RCSB], [https://www.ebi.ac.uk/pdbsum/5ggb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ggb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ggb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ggb OCA], [http://pdbe.org/5ggb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ggb RCSB], [http://www.ebi.ac.uk/pdbsum/5ggb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ggb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MUTT1_MYCS2 MUTT1_MYCS2] Catalyzes the conversion of 8-oxo-dGTP to 8-oxo-dGDP, and 8-oxo-GTP to 8-oxo-GDP (PubMed:16585780, PubMed:28375146). At high enzyme concentrations, can also catalyze the conversion of 8-oxo-dGDP to 8-oxo-dGMP, and 8-oxo-GDP to 8-oxo-GMP (PubMed:28375146). In addition, catalyzes the hydrolysis of the diadenosine polyphosphates diadenosine hexaphosphate (Ap6A), diadenosine pentaphosphate (Ap5A) and diadenosine tetraphosphate (Ap4A) (PubMed:28705712).<ref>PMID:16585780</ref> <ref>PMID:28375146</ref> <ref>PMID:28705712</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 21:


==See Also==
==See Also==
*[[Nudix hydrolase 3D structures|Nudix hydrolase 3D structures]]
*[[7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures|7%2C8-dihydro-8-oxoguanine triphosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 26: Line 27:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mycs2]]
[[Category: Mycolicibacterium smegmatis MC2 155]]
[[Category: Arif, S M]]
[[Category: Arif SM]]
[[Category: Patil, A G]]
[[Category: Patil AG]]
[[Category: Varshney, U]]
[[Category: Varshney U]]
[[Category: Vijayan, M]]
[[Category: Vijayan M]]
[[Category: 8-oxo-guanine nucleotide]]
[[Category: Binding sites at intermolecular interface]]
[[Category: Enzyme action]]
[[Category: Histidine phosphatase domain]]
[[Category: Hydrolase]]
[[Category: Nudix enzyme]]
[[Category: Sanitization of nucleotide pool]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA