1an9: Difference between revisions

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<StructureSection load='1an9' size='340' side='right'caption='[[1an9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1an9' size='340' side='right'caption='[[1an9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1an9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AN9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1an9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AN9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE2:2-AMINOBENZOIC+ACID'>BE2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE2:2-AMINOBENZOIC+ACID'>BE2</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1an9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1an9 OCA], [https://pdbe.org/1an9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1an9 RCSB], [https://www.ebi.ac.uk/pdbsum/1an9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1an9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1an9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1an9 OCA], [https://pdbe.org/1an9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1an9 RCSB], [https://www.ebi.ac.uk/pdbsum/1an9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1an9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.  
[https://www.uniprot.org/uniprot/OXDA_PIG OXDA_PIG] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: D-amino-acid oxidase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pig]]
[[Category: Sus scrofa]]
[[Category: Hirotsu, K]]
[[Category: Hirotsu K]]
[[Category: Miura, R]]
[[Category: Miura R]]
[[Category: Miyahara, I]]
[[Category: Miyahara I]]
[[Category: Mizutani, H]]
[[Category: Mizutani H]]
[[Category: Nishina, Y]]
[[Category: Nishina Y]]
[[Category: Setoyama, C]]
[[Category: Setoyama C]]
[[Category: Shiga, K]]
[[Category: Shiga K]]
[[Category: D-amino acid]]
[[Category: Fad]]
[[Category: Flavoprotein]]
[[Category: Oxidase]]
[[Category: Oxidoreductase]]

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