1aax: Difference between revisions
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<StructureSection load='1aax' size='340' side='right'caption='[[1aax]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1aax' size='340' side='right'caption='[[1aax]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1aax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1aax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AAX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BPM:4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN'>BPM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aax OCA], [https://pdbe.org/1aax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aax RCSB], [https://www.ebi.ac.uk/pdbsum/1aax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aax ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aax OCA], [https://pdbe.org/1aax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aax RCSB], [https://www.ebi.ac.uk/pdbsum/1aax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aax ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Almo SC]] | |||
[[Category: Almo | [[Category: Lawrence D]] | ||
[[Category: Lawrence | [[Category: Puius YA]] | ||
[[Category: Puius | [[Category: Sullivan M]] | ||
[[Category: Sullivan | [[Category: Zhang Z-Y]] | ||
[[Category: Zhang | [[Category: Zhao Y]] | ||
[[Category: Zhao | |||