5fpl: Difference between revisions

<table><tr><td colspan='2'>[[5fpl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FPL FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=QAY:8-[4-(2-AZANYLETHYL)PYRAZOL-1-YL]-3H-PYRIDO[3,4-D]PYRIMIDIN-4-ONE'>QAY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpl OCA], [https://pdbe.org/5fpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fpl RCSB], [https://www.ebi.ac.uk/pdbsum/5fpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpl ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>  

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: Bountra C]]

[[Category: Brennan P]]

[[Category: Edwards A]]

[[Category: Gileadi C]]

[[Category: Huber K]]

[[Category: Johansson C]]

[[Category: Nowak R]]

[[Category: Oppermann U]]

[[Category: Srikannathasan V]]

[[Category: Yann-Vai LB]]

[[Category: Von Delft F]]