7ga3: Difference between revisions

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-'''Unreleased structure'''
-The entry 7ga3 is ON HOLD
+==PanDDA analysis group deposition -- Crystal Structure of Zika virus NS3 Helicase in complex with Z3241250482==
+<StructureSection load='7ga3' size='340' side='right'caption='[[7ga3]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
-Authors: Godoy, A.S., Noske, G.D., Fairhead, M., Lithgo, R.M., Koekemoer, L., Aschenbrenner, J.C., Balcomb, B.H., Marples, P.G., Ni, X., Tomlinson, C.W.E., Wild, C., Mesquita, N.C.M.R., Oliva, G., Fearon, D., Walsh, M.A., von Delft, F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ga3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7GA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7GA3 FirstGlance]. <br>
-Description: THE CRYSTAL STRUCTURE OF ZIKA VIRUS NS3 HELICASE DOMAIN
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.809&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HV2:1,1-bis(oxidanylidene)thietan-3-ol'>HV2</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-[[Category: Noske, G.D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ga3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ga3 OCA], [https://pdbe.org/7ga3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ga3 RCSB], [https://www.ebi.ac.uk/pdbsum/7ga3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ga3 ProSAT]</span></td></tr>
-[[Category: Balcomb, B.H]]
+</table>
-[[Category: Mesquita, N.C.M.R]]
+== Function ==
-[[Category: Lithgo, R.M]]
+[https://www.uniprot.org/uniprot/POLG_ZIKV POLG_ZIKV] Protein C: Encapsulates the genomic RNA.[UniProtKB:P17763]  prM: Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.[UniProtKB:P17763]  Envelope protein E: Binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.[UniProtKB:P17763]  Non-structural protein 1: Involved in virus replication and regulation of the innate immune response.[UniProtKB:P17763]  Non-structural protein 2A: May be involved viral RNA replication and capsid assembly.[UniProtKB:P09732]  Non-structural protein 4A: Induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the helicase region of Serine protease NS3 chain.[UniProtKB:P17763]  Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763]  Non-structural protein 4B: Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:P17763]
-[[Category: Godoy, A.S]]
+__TOC__
-[[Category: Fearon, D]]
+</StructureSection>
-[[Category: Walsh, M.A]]
+[[Category: Large Structures]]
-[[Category: Oliva, G]]
+[[Category: Zika virus]]
-[[Category: Fairhead, M]]
+[[Category: Aschenbrenner JC]]
-[[Category: Von Delft, F]]
+[[Category: Balcomb BH]]
-[[Category: Marples, P.G]]
+[[Category: Fairhead M]]
-[[Category: Koekemoer, L]]
+[[Category: Fearon D]]
-[[Category: Wild, C]]
+[[Category: Godoy AS]]
-[[Category: Ni, X]]
+[[Category: Koekemoer L]]
-[[Category: Aschenbrenner, J.C]]
+[[Category: Lithgo RM]]
-[[Category: Tomlinson, C.W.E]]
+[[Category: Marples PG]]
+[[Category: Mesquita NCMR]]
+[[Category: Ni X]]
+[[Category: Noske GD]]
+[[Category: Oliva G]]
+[[Category: Tomlinson CWE]]
+[[Category: Walsh MA]]
+[[Category: Wild C]]
+[[Category: Von Delft F]]