5fis: Difference between revisions
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<StructureSection load='5fis' size='340' side='right'caption='[[5fis]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='5fis' size='340' side='right'caption='[[5fis]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5fis]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5fis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FIS FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fis OCA], [https://pdbe.org/5fis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fis RCSB], [https://www.ebi.ac.uk/pdbsum/5fis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fis ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/EXD1_BOMMO EXD1_BOMMO] RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.<ref>PMID:26669262</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bombyx mori]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Chen KM]] | ||
[[Category: Fauvarque | [[Category: Fauvarque MO]] | ||
[[Category: Homolka | [[Category: Homolka D]] | ||
[[Category: McCarthy AA]] | |||
[[Category: McCarthy | [[Category: Pandey RR]] | ||
[[Category: Pandey | [[Category: Pillai RS]] | ||
[[Category: Pillai | [[Category: Reuter M]] | ||
[[Category: Reuter | [[Category: Rodino Janeiro BK]] | ||
[[Category: | [[Category: Sachidanandam R]] | ||
[[Category: | [[Category: Yang Z]] | ||
[[Category: | |||