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==Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2== | |||
<StructureSection load='8sg7' size='340' side='right'caption='[[8sg7]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8sg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bat_adeno-associated_virus Bat adeno-associated virus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SG7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sg7 OCA], [https://pdbe.org/8sg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sg7 RCSB], [https://www.ebi.ac.uk/pdbsum/8sg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sg7 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Forwood | == Function == | ||
[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bat adeno-associated virus]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Forwood JK]] | |||
[[Category: Hoad M]] | |||
Latest revision as of 09:16, 19 July 2023
Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2
Structural highlights
FunctionIMA1_MOUSE Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
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