5egm: Difference between revisions

<StructureSection load='5egm' size='340' side='right'caption='[[5egm]], [[Resolution|resolution]] 1.84&Aring;' scene=''>

<table><tr><td colspan='2'>[[5egm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EGM FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.841&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5NY:2-CHLORANYL-~{N}-[(7~{S})-2-METHYL-7-PHENYL-10-(1~{H}-1,2,3,4-TETRAZOL-5-YL)-8,9-DIHYDRO-6~{H}-PYRIDO[1,2-A]INDOL-7-YL]-4-(1,2,4-TRIAZOL-4-YL)BENZAMIDE'>5NY</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5egm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5egm OCA], [https://pdbe.org/5egm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5egm RCSB], [https://www.ebi.ac.uk/pdbsum/5egm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5egm ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FA9_HUMAN FA9_HUMAN] Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:[https://omim.org/entry/306900 306900]; also known as Christmas disease.<ref>PMID:8295821</ref> <ref>PMID:2592373</ref> <ref>PMID:2743975</ref> <ref>PMID:6603618</ref> <ref>PMID:3009023</ref> <ref>PMID:3790720</ref> <ref>PMID:3401602</ref> <ref>PMID:3243764</ref> <ref>PMID:2713493</ref> <ref>PMID:2714791</ref> <ref>PMID:2773937</ref> <ref>PMID:2775660</ref> <ref>PMID:2753873</ref> <ref>PMID:2738071</ref> <ref>PMID:2472424</ref> <ref>PMID:2339358</ref> <ref>PMID:2372509</ref> <ref>PMID:2162822</ref> <ref>PMID:1958666</ref> <ref>PMID:1902289</ref> <ref>PMID:1346975</ref> <ref>PMID:1615485</ref> <ref>PMID:8257988</ref> <ref>PMID:8076946</ref> <ref>PMID:8199596</ref> <ref>PMID:7981722</ref> <ref>PMID:8680410</ref> <ref>PMID:9222764</ref> <ref>PMID:9590153</ref> <ref>PMID:9452115</ref> <ref>PMID:9600455</ref> <ref>PMID:10698280</ref> <ref>PMID:10094553</ref> <ref>PMID:11122099</ref> <ref>PMID:12588353</ref> <ref>PMID:12604421</ref>  Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.  Defects in F9 are the cause of thrombophilia due to factor IX defect (THPH8) [MIM:[https://omim.org/entry/300807 300807]. A hemostatic disorder characterized by a tendency to thrombosis.<ref>PMID:19846852</ref>  

[https://www.uniprot.org/uniprot/FA9_HUMAN FA9_HUMAN] Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Andre P]]

[[Category: Araki K]]

[[Category: Bateman TJ]]

[[Category: Berger R]]

[[Category: Campeau L]]

[[Category: Chen Y]]

[[Category: Desai K]]

[[Category: Dewnani S]]

[[Category: Ellsworth K]]

[[Category: Feng D]]

[[Category: Geissler WM]]

[[Category: Guo L]]

[[Category: Hirabayashi T]]

[[Category: Hruza A]]

[[Category: Jian T]]

[[Category: Li H]]

[[Category: McCabe-Dunn j]]

[[Category: Meng D]]

[[Category: Nishimura T]]

[[Category: Orr R]]

[[Category: Parker DL]]

[[Category: Poirier M]]

[[Category: Reichert P]]

[[Category: Sakurada I]]

[[Category: Sherer EC]]

[[Category: Smith CJ]]

[[Category: Sonatore LM]]

[[Category: Tschirret-Guth R]]

[[Category: Wood HB]]

[[Category: Wu J]]

[[Category: Xu J]]

[[Category: Zhang T]]