5e8o: Difference between revisions

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<StructureSection load='5e8o' size='340' side='right'caption='[[5e8o]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
<StructureSection load='5e8o' size='340' side='right'caption='[[5e8o]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e8o]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E8O FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e8o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E8O FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sphingosine_N-acyltransferase Sphingosine N-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.24 2.3.1.24] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8o OCA], [https://pdbe.org/5e8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e8o RCSB], [https://www.ebi.ac.uk/pdbsum/5e8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8o OCA], [http://pdbe.org/5e8o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8o RCSB], [http://www.ebi.ac.uk/pdbsum/5e8o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e8o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/CERS5_MOUSE CERS5_MOUSE]] Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1.<ref>PMID:12912983</ref> <ref>PMID:16100120</ref> 
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Sphingosine N-acyltransferase]]
[[Category: Achour A]]
[[Category: Achour, A]]
[[Category: Buratto J]]
[[Category: Buratto, J]]
[[Category: Doorduijn E]]
[[Category: Doorduijn, E]]
[[Category: Duru AD]]
[[Category: Duru, A D]]
[[Category: Hafstrand I]]
[[Category: Hafstrand, I]]
[[Category: Oliveira CC]]
[[Category: Hall, T van]]
[[Category: Sandalova T]]
[[Category: Oliveira, C C]]
[[Category: Van Hall T]]
[[Category: Sandalova, T]]
[[Category: Cancer]]
[[Category: Immune system]]
[[Category: Mhc-i]]
[[Category: Neo-epitope]]
[[Category: Non-canonical peptide binding]]
[[Category: Sulfur-pi interaction]]
[[Category: Tap-deficiency]]
[[Category: Teipp]]

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