1tox: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TOX FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tox]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynephage_beta Corynephage beta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TOX FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tox OCA], [https://pdbe.org/1tox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tox RCSB], [https://www.ebi.ac.uk/pdbsum/1tox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tox ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tox OCA], [https://pdbe.org/1tox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tox RCSB], [https://www.ebi.ac.uk/pdbsum/1tox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tox ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DTX_CORBE DTX_CORBE] Diphtheria toxin, produced by a phage infecting Corynebacterium diphtheriae, is a proenzyme that, after activation, catalyzes the covalent attachment of the ADP ribose moiety of NAD to eukaryotic elongation factor 2 (eEF-2). Fragment A is the catalytic portion responsible for enzymatic ADP-ribosylation of elongation factor 2, while fragment B is responsible for binding of toxin to cell receptors and entry of fragment A.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Corynephage beta]] | [[Category: Corynephage beta]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bell | [[Category: Bell CE]] | ||
[[Category: Eisenberg | [[Category: Eisenberg D]] | ||