Catalase: Difference between revisions
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[[Image:Catalases MotM57.png| Three types of catalases. The first two (human and bacterial) use hemoglobin-bound iron to bind to oxygen, while the third (a pseudocatalase) uses manganese. From [https://pdb101.rcsb.org/motm/57 Molecule of the Month] (RCSB PDB) by David Goodsell] based on PDB-IDs 1qqw, 1iph, and 1jku.|thumb|500px|right]] | |||
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'''Catalase''' (CAT) catalyzes the conversion of hydrogen peroxide to water and oxygen. CAT contains porphyrin-heme Fe group which reacts with the hydrogen peroxide. CAT containing Mn are called pseudocatalase (PCAT).<ref>PMID:21524057</ref> '''Catalase-peroxidase''' (CAT KatG) is a bifunctional enzyme with both catalase and peroxidase activities. CAT KatG cofactor is a heme group. It provides defense against oxidative stress by reducing hydrogen peroxide. Mutations in CAT KatG can cause resistance to the anti-malarial drug isoniazid (INH).<ref>PMID:15231843</ref> '''Catalase-phenol oxidase''' (CATPO) is a heme-containing CAT which shows phenol oxidase activity.<ref>PMID:22370948</ref> | '''Catalase''' (CAT) catalyzes the conversion of hydrogen peroxide to water and oxygen. CAT contains porphyrin-heme Fe group which reacts with the hydrogen peroxide. CAT containing Mn are called pseudocatalase (PCAT).<ref>PMID:21524057</ref> '''Catalase-peroxidase''' (CAT KatG) is a bifunctional enzyme with both catalase and peroxidase activities. CAT KatG cofactor is a heme group. It provides defense against oxidative stress by reducing hydrogen peroxide. Mutations in CAT KatG can cause resistance to the anti-malarial drug isoniazid (INH).<ref>PMID:15231843</ref> '''Catalase-phenol oxidase''' (CATPO) is a heme-containing CAT which shows phenol oxidase activity.<ref>PMID:22370948</ref> | ||
[[Image:Catalase net reaction.png|700px]] | |||
<StructureSection load='1gge' size='350' side='right' scene='46/467276/Cv/1' caption='E. coli catalase Hpii tetramer showing the heme group, [[1gge]]'> | |||
== Structure == | == Structure == | ||