Phosphoenolpyruvate carboxylase: Difference between revisions

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Although all enzymes of the C4 cycle are present in C3 plants, there are important changes found in C4 isoforms, specially in PEPC enzymes, that make C4 metabolism possible. PEPC’s have several non-photosynthetic related functions in different plant tissues. In C4 plants, however, changes in the promotor and enzyme structures allow for strong and specific mesophyll expression, reduced sensitivity to negative feedback inhibitors and higher kinetic efficiency <ref name="blasing2000"/><ref>PMID: 12781769</ref><ref name="Paulus2013"/>. Without this characteristics, efficient carbon fixation in the mesophyll and subsequent carbon concentration in the BS wouldn’t be possible. Therefore, the evolution  of PEPC’s C4 isoforms is one of the most important steps in the establishment of the C4 pathway <ref name="sage2004"/>.
Although all enzymes of the C4 cycle are present in C3 plants, there are important changes found in C4 isoforms, specially in PEPC enzymes, that make C4 metabolism possible. PEPC’s have several non-photosynthetic related functions in different plant tissues. In C4 plants, however, changes in the promotor and enzyme structures allow for strong and specific mesophyll expression, reduced sensitivity to negative feedback inhibitors and higher kinetic efficiency <ref name="blasing2000"/><ref>PMID: 12781769</ref><ref name="Paulus2013"/>. Without this characteristics, efficient carbon fixation in the mesophyll and subsequent carbon concentration in the BS wouldn’t be possible. Therefore, the evolution  of PEPC’s C4 isoforms is one of the most important steps in the establishment of the C4 pathway <ref name="sage2004"/>.


<StructureSection load='' size='400' side='right' scene='57/573979/Tetramer/1' pspeed='8'>
<StructureSection load='' size='400' side='right' scene='57/573979/Tetramer/2' pspeed='8'>
== PEPC enzyme structure ==
== PEPC enzyme structure ==


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Michal Harel, Alexander Berchansky, Joel L. Sussman, Lucas Xavier da Cunha, Karsten Theis