Diclofenac: Difference between revisions
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Diclofenac has a relatively high lipid solubility, making it one of the few NSAIDs that are able to enter the brain by crossing the blood-brain barrier. In the brain, too, it is thought to exert its effect through inhibition of COX-2.<ref name="a44">PMID:25078485</ref> In addition, it may have effects inside the spinal cord.<ref name="a45">PMID:27014880</ref>. | Diclofenac has a relatively high lipid solubility, making it one of the few NSAIDs that are able to enter the brain by crossing the blood-brain barrier. In the brain, too, it is thought to exert its effect through inhibition of COX-2.<ref name="a44">PMID:25078485</ref> In addition, it may have effects inside the spinal cord.<ref name="a45">PMID:27014880</ref>. | ||
It also may inhibit [[phospholipase A2]] as part of its mechanism of action. These additional actions may explain its high potency – it is the most potent NSAID on a broad basis.<ref name="a46">PMID:3085490</ref> <scene name='97/974935/Cv/2'>Crystal structure of the complex formed between phospholipase A2 and diclofenac</scene> ([[2b17]]). | It also may inhibit [[phospholipase A2]] as part of its mechanism of action. These additional actions may explain its high potency – it is the most potent NSAID on a broad basis.<ref name="a46">PMID:3085490</ref> <scene name='97/974935/Cv/2'>Crystal structure of the complex formed between phospholipase A2 and diclofenac</scene> ([[2b17]]). <scene name='97/974935/Binding_site/1'>Diclofenac binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||