Aspirin: Difference between revisions
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='97/974928/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='97/974928/Cv/1'> | ||
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. See also [https://en.wikipedia.org/wiki/Aspirin]. | Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. See also [https://en.wikipedia.org/wiki/Aspirin]. | ||
Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX; officially known as prostaglandin-endoperoxide synthase, PTGS) enzyme required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the PTGS enzyme (Suicide inhibition). This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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