1le0: Difference between revisions

Revision as of 23:49, 2 May 2008

NMR structure of Tryptophan Zipper 1: a stable, monomeric beta-hairpin with a type II' turn

OverviewOverview

A structural motif, the tryptophan zipper (trpzip), greatly stabilizes the beta-hairpin conformation in short peptides. Peptides (12 or 16 aa in length) with four different turn sequences are monomeric and fold cooperatively in water, as has been observed previously for some hairpin peptides. However, the folding free energies of the trpzips exceed substantially those of all previously reported beta-hairpins and even those of some larger designed proteins. NMR structures of three of the trpzip peptides reveal exceptionally well-defined beta-hairpin conformations stabilized by cross-strand pairs of indole rings. The trpzips are the smallest peptides to adopt an unique tertiary fold without requiring metal binding, unusual amino acids, or disulfide crosslinks.

About this StructureAbout this Structure

This structure supersedes the now removed PDB entry 1hrw. Full crystallographic information is available from OCA.

ReferenceReference

Tryptophan zippers: stable, monomeric beta -hairpins., Cochran AG, Skelton NJ, Starovasnik MA, Proc Natl Acad Sci U S A. 2001 May 8;98(10):5578-83. Epub 2001 May 1. PMID:11331745 Page seeded by OCA on Fri May 2 23:49:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1le0.jpg|left|200px]]
- {{Structure
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-}}
 '''NMR structure of Tryptophan Zipper 1: a stable, monomeric beta-hairpin with a type II' turn'''
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 ==About this Structure==
-LE0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. This structure supersedes the now removed PDB entry 1HRW. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LE0 OCA].
+This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hrw 1hrw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LE0 OCA].
 ==Reference==
 Tryptophan zippers: stable, monomeric beta -hairpins., Cochran AG, Skelton NJ, Starovasnik MA, Proc Natl Acad Sci U S A. 2001 May 8;98(10):5578-83. Epub 2001 May 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11331745 11331745]
-[[Category: Protein complex]]
 [[Category: Cochran, A G.]]
 [[Category: Skelton, N J.]]
 [[Category: Starovasnik, M A.]]
-[[Category: beta-hairpin]]
+[[Category: Beta-hairpin]]
-[[Category: type ii' turn]]
+[[Category: Type ii' turn]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:49:55 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:01:39 2008''