5dim: Difference between revisions

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<StructureSection load='5dim' size='340' side='right'caption='[[5dim]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
<StructureSection load='5dim' size='340' side='right'caption='[[5dim]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5dim]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clope Clope]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DIM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5dim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens_str._13 Clostridium perfringens str. 13]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DIM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pfo, pfoA, pfoR, CPE0163 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195102 CLOPE])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dim OCA], [http://pdbe.org/5dim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dim RCSB], [http://www.ebi.ac.uk/pdbsum/5dim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dim ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dim OCA], [https://pdbe.org/5dim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dim RCSB], [https://www.ebi.ac.uk/pdbsum/5dim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dim ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref>
[https://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Clope]]
[[Category: Clostridium perfringens str. 13]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gorman, M A]]
[[Category: Gorman MA]]
[[Category: Lawrence, S L]]
[[Category: Lawrence SL]]
[[Category: Parker, M W]]
[[Category: Parker MW]]
[[Category: Mutant]]
[[Category: Toxin]]

Latest revision as of 00:43, 29 June 2023

Mutant toxin in 'native' space groupMutant toxin in 'native' space group

Structural highlights

5dim is a 1 chain structure with sequence from Clostridium perfringens str. 13. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.32Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TACY_CLOPE Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.[1]

See Also

References

  1. ↑ Rossjohn J, Polekhina G, Feil SC, Morton CJ, Tweten RK, Parker MW. Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol. 2007 Apr 13;367(5):1227-36. Epub 2007 Jan 23. PMID:17328912 doi:http://dx.doi.org/10.1016/j.jmb.2007.01.042

5dim, resolution 3.32Å

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