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==NMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURES==
==NMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURES==
<StructureSection load='1roo' size='340' side='right'caption='[[1roo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1roo' size='340' side='right'caption='[[1roo]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1roo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stihl Stihl]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ROO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ROO FirstGlance]. <br>
<table><tr><td colspan='2'>[[1roo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ROO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ROO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1roo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1roo OCA], [https://pdbe.org/1roo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1roo RCSB], [https://www.ebi.ac.uk/pdbsum/1roo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1roo ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1roo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1roo OCA], [https://pdbe.org/1roo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1roo RCSB], [https://www.ebi.ac.uk/pdbsum/1roo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1roo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TXSHK_STOHE TXSHK_STOHE]] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>
[https://www.uniprot.org/uniprot/K1A_STIHL K1A_STIHL] Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.<ref>PMID:7660365</ref>  


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Stihl]]
[[Category: Stichodactyla helianthus]]
[[Category: Norton, R S]]
[[Category: Norton RS]]
[[Category: Pallaghy, P K]]
[[Category: Pallaghy PK]]
[[Category: Pennington, M W]]
[[Category: Pennington MW]]
[[Category: Tudor, J E]]
[[Category: Tudor JE]]
[[Category: Neurotoxin]]
[[Category: Potassium channel inhibitor]]

Revision as of 00:34, 29 June 2023

NMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURESNMR SOLUTION STRUCTURE OF SHK TOXIN, NMR, 20 STRUCTURES

Structural highlights

1roo is a 1 chain structure with sequence from Stichodactyla helianthus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

K1A_STIHL Inhibits voltage-dependent potassium channels. Inhibits Kv1.3/KCNA3 potently and also blocks Kv1.1/KCNA1, Kv1.4/KCNA4, and Kv1.6/KCNA6 at subnanomolar concentrations.[1]

See Also

References

  1. ↑ Castaneda O, Sotolongo V, Amor AM, Stocklin R, Anderson AJ, Harvey AL, Engstrom A, Wernstedt C, Karlsson E. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33(5):603-13. PMID:7660365
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