User:Daniel Key Takemoto/Sandbox 2: Difference between revisions

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The K-homology domain (KH domain) folding is similar to other RBPs domains, which play an important role in RNA binding and protein-protein interactions.

Here it is the KH0 MOTIF highlighted in red. Many RNA-binding proteins contain the KH motif, a conserved RNA-binding domain, but different from the KH1 and KH2 motifs, which contain a GXXG canonical motif, that will be explained in further details in the next topic, instead this one has an A-K-E-A. It is most likely involved in RNA binding and regulation, as seen in other proteins that also contain KH motifs. To give a more thorough response addressing the precise role played by the KH theme in FMRP, additional details would be needed. The THREE BETA SHEETS OF THE KH0 MOTIF

Here it is the <scene name='97/973970/Kh0_domain/1'>KH0 MOTIF</scene> highlighted in red. Many RNA-binding proteins contain the KH motif, a conserved RNA-binding domain, but different from the KH1 and KH2 motifs, which contain a GXXG canonical motif, that will be explained in further details in the next topic, instead this one has an A-K-E-A. It is most likely involved in RNA binding and regulation, as seen in other proteins that also contain KH motifs. To give a more thorough response addressing the precise role played by the KH theme in FMRP, additional details would be needed. The THREE BETA SHEETS OF THE KH0 MOTIF

Overall, the FMRP NTD plays an important role as an RNA-binding protein, and its involvement in RNP complexes and its specific domains and motifs allow it to bind to specific RNAs and regulate their translation. <ref>MYRICK, L. K. et al. Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain. Human Molecular Genetics, v. 24, n. 6, p. 1733–1740, 20 nov. 2014.[https://doi.org/10.1093/hmg/ddu586]</ref>

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 The K-homology domain (KH domain) folding is similar to other RBPs domains, which play an important role in RNA binding and protein-protein interactions.
-Here it is the KH0 MOTIF highlighted in red. Many RNA-binding proteins contain the KH motif, a conserved RNA-binding domain, but different from the KH1 and KH2 motifs, which contain a GXXG canonical motif, that will be explained in further details in the next topic, instead this one has an A-K-E-A. It is most likely involved in RNA binding and regulation, as seen in other proteins that also contain KH motifs. To give a more thorough response addressing the precise role played by the KH theme in FMRP, additional details would be needed. The THREE BETA SHEETS OF THE KH0 MOTIF
+Here it is the <scene name='97/973970/Kh0_domain/1'>KH0 MOTIF</scene> highlighted in red. Many RNA-binding proteins contain the KH motif, a conserved RNA-binding domain, but different from the KH1 and KH2 motifs, which contain a GXXG canonical motif, that will be explained in further details in the next topic, instead this one has an A-K-E-A. It is most likely involved in RNA binding and regulation, as seen in other proteins that also contain KH motifs. To give a more thorough response addressing the precise role played by the KH theme in FMRP, additional details would be needed. The THREE BETA SHEETS OF THE KH0 MOTIF
 Overall, the FMRP NTD plays an important role as an RNA-binding protein, and its involvement in RNP complexes and its specific domains and motifs allow it to bind to specific RNAs and regulate their translation. <ref>MYRICK, L. K. et al. Human FMRP contains an integral tandem Agenet (Tudor) and KH motif in the amino terminal domain. Human Molecular Genetics, v. 24, n. 6, p. 1733–1740, 20 nov. 2014.[https://doi.org/10.1093/hmg/ddu586]</ref>