8srm: Difference between revisions

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-'''Unreleased structure'''
-The entry 8srm is ON HOLD
+==Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant==
+<StructureSection load='8srm' size='340' side='right'caption='[[8srm]], [[Resolution|resolution]] 4.46&Aring;' scene=''>
-Authors: Chen, M., Hurley, J.H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8srm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRM FirstGlance]. <br>
-Description: Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8srm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8srm OCA], [https://pdbe.org/8srm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8srm RCSB], [https://www.ebi.ac.uk/pdbsum/8srm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8srm ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Chen, M]]
+== Function ==
-[[Category: Hurley, J.H]]
+[https://www.uniprot.org/uniprot/RBCC1_HUMAN RBCC1_HUMAN] Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (By similarity). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (By similarity). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (By similarity). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity).[UniProtKB:Q9ESK9]<ref>PMID:10769033</ref> <ref>PMID:12095676</ref> <ref>PMID:12163359</ref> <ref>PMID:12221124</ref> <ref>PMID:14533007</ref> <ref>PMID:21775823</ref> <ref>PMID:23392225</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen M]]
+[[Category: Hurley JH]]