Lysin

Function Lysin (Lys) is a protein which cleaves cell walls. Egg Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg. Structural highlights The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic molecule. . you can see the alpha helixes in pink. exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of ,(in green) and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action. 3D structure of lysin Lysin 3D structures Updated on 30-May-2025 1lis, 1lyn, 2lis, 2lyn, 3lyn, 5ii7, 5ii8, 5ii9 – aLys - abalone 5utg – aLys (mutant) 5iia, 5iib, 5mr3 – aLys + vitelline envelope sperm lysin receptor 1nkl – NK-Lys – pig – NMR 4cvd – Lys – bacteriophage CP-7 6ilu – Lys – bacteriophage PBC5 5kgr, 6ist, 6l00 – EpLys – Enterococcus phage IMEEF1 5jgr, 7dws – T4Lys – Enterobacteria phage T4 4w51, 4w52, 4w53, 4w54, 4w55, 4w56, 4w57, 4w58, 4w59, 5jgn, 5jgt, 5jgu, 5jgv, 5jgx, 5jgz, 5lwo, 5nx0 – T4Lys (mutant) 5g27, 5jws, 5jwt, 5jwu, 5jwv, 5jww – T4Lys (mutant) + azaborine 1h09 – bLys – bacteriophage CP-1 1oba – bLys + choline 2ixu – bLys + peptidoglycan analog 2ixv, 2j8f, 2j8g – bLys (mutant) + peptidoglycan analog 5khz, 5vnq, 6ph0, 6ph1, 6u0b, 6u0c, 6u0e, 6u0f, 6v51, 7m5i – EcLys – E. coli phage 5ki1, 5ki2, 5ki3, 5ki8, 5kig, 5kii, 5kim, 5kio, 5xpe, 6pgy, 6pgz – EcLys (mutant) 6akv – Lys – B. cereus phage 6fhg – Lys – Thermus phage 7kwt, 7kww, 7kwy – PLyCB (mutant) – Streptococcus phage 7aqh – PLyCB cell wall-binding domain 6yj1 – PLyCB peptidase domain 4jz5 – Ply40 catalytic domain – Listeria phage 4krt – Lys – Clostridium phage 2mk5 – GH15Lys residues 368-495 – phage GH15 – NMR 4olk – GH15Lys CHAP domain residues 1-165 4ols – GH15Lys amidase domain residues 165-403

spinqualitylabelsall models Abalone lysin (PDB code 1lis) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image