5cs9: Difference between revisions

<StructureSection load='5cs9' size='340' side='right'caption='[[5cs9]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[5cs9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CS9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CS9 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cs9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cs9 OCA], [https://pdbe.org/5cs9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cs9 RCSB], [https://www.ebi.ac.uk/pdbsum/5cs9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cs9 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[https://omim.org/entry/608265 608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>  

[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Ascher DB]]

[[Category: Blundell TL]]

[[Category: Chirgadze DY]]

[[Category: Fragai M]]

[[Category: Gherardi E]]

[[Category: Sigurdardottir AG]]

[[Category: Sobkowicz A]]

[[Category: Winter A]]