5cef: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 3: Line 3:
<StructureSection load='5cef' size='340' side='right'caption='[[5cef]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5cef' size='340' side='right'caption='[[5cef]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Crynj Crynj]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CEF FirstGlance]. <br>
<table><tr><td colspan='2'>[[5cef]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryptococcus_neoformans_var._neoformans_JEC21 Cryptococcus neoformans var. neoformans JEC21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CEF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CNA02450 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214684 CRYNJ])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [https://pdbe.org/5cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [https://www.ebi.ac.uk/pdbsum/5cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cef OCA], [http://pdbe.org/5cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cef RCSB], [http://www.ebi.ac.uk/pdbsum/5cef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cef ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5KPK7_CRYNJ Q5KPK7_CRYNJ]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 25:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aspartate-semialdehyde dehydrogenase]]
[[Category: Cryptococcus neoformans var. neoformans JEC21]]
[[Category: Crynj]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dahal, G P]]
[[Category: Dahal GP]]
[[Category: Viola, R E]]
[[Category: Viola RE]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]

Revision as of 15:01, 14 June 2023

Cystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformansCystal structure of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans

Structural highlights

5cef is a 4 chain structure with sequence from Cryptococcus neoformans var. neoformans JEC21. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q5KPK7_CRYNJ

Publication Abstract from PubMed

Aspartate semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate-biosynthetic pathway and represents a valid target for antimicrobial drug design. This enzyme catalyzes the NADPH-dependent reductive dephosphorylation of beta-aspartyl phosphate to produce the key intermediate aspartate semialdehyde. Production of this intermediate represents the first committed step in the biosynthesis of the essential amino acids methionine, isoleucine and threonine in fungi, and also the amino acid lysine in bacteria. The structure of a new fungal form of ASADH from Cryptococcus neoformans has been determined to 2.6 A resolution. The overall structure of CnASADH is similar to those of its bacterial orthologs, but with some critical differences both in biological assembly and in secondary-structural features that can potentially be exploited for the development of species-selective drugs.

Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans.,Dahal G, Viola RE Acta Crystallogr F Struct Biol Commun. 2015 Nov 1;71(Pt 11):1365-71. doi:, 10.1107/S2053230X15017495. Epub 2015 Oct 23. PMID:26527262[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Dahal G, Viola RE. Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans. Acta Crystallogr F Struct Biol Commun. 2015 Nov 1;71(Pt 11):1365-71. doi:, 10.1107/S2053230X15017495. Epub 2015 Oct 23. PMID:26527262 doi:http://dx.doi.org/10.1107/S2053230X15017495

5cef, resolution 2.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=5cef&oldid=3790007"