6d9p: Difference between revisions

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==NMR solution structure of tamapin, mutant K27A==
==NMR solution structure of tamapin, mutant K27A==
<StructureSection load='6d9p' size='340' side='right'caption='[[6d9p]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='6d9p' size='340' side='right'caption='[[6d9p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6d9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_tamalus Buthus tamalus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D9P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6D9P FirstGlance]. <br>
<table><tr><td colspan='2'>[[6d9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D9P FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6d9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d9p OCA], [http://pdbe.org/6d9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d9p RCSB], [http://www.ebi.ac.uk/pdbsum/6d9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d9p ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d9p OCA], [https://pdbe.org/6d9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d9p RCSB], [https://www.ebi.ac.uk/pdbsum/6d9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d9p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KAX54_MESTA KAX54_MESTA]] Blocks small conductance calcium-activated potassium channels in pyramidal neurons of the hippocampus. Displays a unique, remarkable selectivity for SK2/KCNN2 versus SK1/KCNN1 and SK3/KCNN3 channels.<ref>PMID:12239213</ref>
[https://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buthus tamalus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Delgado, G A.Titaux]]
[[Category: Mesobuthus tamulus]]
[[Category: Flores, M Mayorga]]
[[Category: Mayorga Flores M]]
[[Category: Meneses, C M.Melchor]]
[[Category: Melchor Meneses CM]]
[[Category: Portilla, F del Rio]]
[[Category: Titaux Delgado GA]]
[[Category: Csalpha/beta]]
[[Category: Del Rio Portilla F]]
[[Category: K27a]]
[[Category: Sk channel]]
[[Category: Tamapin mutant]]
[[Category: Toxin]]

Revision as of 13:42, 14 June 2023

NMR solution structure of tamapin, mutant K27ANMR solution structure of tamapin, mutant K27A

Structural highlights

6d9p is a 1 chain structure with sequence from Mesobuthus tamulus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KAX54_HOTTA Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).[1]

See Also

References

  1. ↑ Pedarzani P, D'hoedt D, Doorty KB, Wadsworth JD, Joseph JS, Jeyaseelan K, Kini RM, Gadre SV, Sapatnekar SM, Stocker M, Strong PN. Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus) that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons. J Biol Chem. 2002 Nov 29;277(48):46101-9. Epub 2002 Sep 17. PMID:12239213 doi:http://dx.doi.org/10.1074/jbc.M206465200
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