6bl9: Difference between revisions
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==NMR Solution structure of U-SLPTX15-Sm2a== | ==NMR Solution structure of U-SLPTX15-Sm2a== | ||
<StructureSection load='6bl9' size='340' side='right'caption='[[6bl9 | <StructureSection load='6bl9' size='340' side='right'caption='[[6bl9]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6bl9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL9 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6bl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scolopendra_morsitans Scolopendra morsitans]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BL9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bl9 OCA], [https://pdbe.org/6bl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bl9 RCSB], [https://www.ebi.ac.uk/pdbsum/6bl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bl9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Scolopendra morsitans]] | ||
[[Category: | [[Category: Craik DJ]] | ||
[[Category: | [[Category: Dash TJ]] | ||
[[Category: | [[Category: Durek T]] | ||
[[Category: | [[Category: Harvey PJ]] | ||
Revision as of 13:38, 14 June 2023
NMR Solution structure of U-SLPTX15-Sm2aNMR Solution structure of U-SLPTX15-Sm2a
Structural highlights
Publication Abstract from PubMedDisulfide-rich peptides (DRPs) play diverse physiological roles and have emerged as attractive sources of pharmacological tools and drug leads. Here we describe the 3D structure of a centipede venom peptide, U-SLPTX15-Sm2a, whose family defines a unique class of one of the most widespread DRP folds known, the cystine-stabilized alpha/beta fold (CSalphabeta). This class, which we have named the two-disulfide CSalphabeta fold (2ds-CSalphabeta), contains only two internal disulfide bonds as opposed to at least three in all other confirmed CSalphabeta peptides, and constitutes one of the major neurotoxic peptide families in centipede venoms. We show the 2ds-CSalphabeta is widely distributed outside centipedes and is likely an ancient fold predating the split between prokaryotes and eukaryotes. Our results provide insights into the ancient evolutionary history of a widespread DRP fold and highlight the usefulness of 3D structures as evolutionary tools. A Centipede Toxin Family Defines an Ancient Class of CSalphabeta Defensins.,Dash TS, Shafee T, Harvey PJ, Zhang C, Peigneur S, Deuis JR, Vetter I, Tytgat J, Anderson MA, Craik DJ, Durek T, Undheim EAB Structure. 2019 Feb 5;27(2):315-326.e7. doi: 10.1016/j.str.2018.10.022. Epub 2018, Dec 13. PMID:30554841[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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