5ujq: Difference between revisions
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==NMR Solution Structure of the Two-component Bacteriocin CbnXY== | ==NMR Solution Structure of the Two-component Bacteriocin CbnXY== | ||
<StructureSection load='5ujq' size='340' side='right'caption='[[5ujq | <StructureSection load='5ujq' size='340' side='right'caption='[[5ujq]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5ujq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJQ OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[5ujq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Carnobacterium_maltaromaticum Carnobacterium maltaromaticum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UJQ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ujq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ujq OCA], [https://pdbe.org/5ujq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ujq RCSB], [https://www.ebi.ac.uk/pdbsum/5ujq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ujq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q46312_CARML Q46312_CARML] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Carnobacterium maltaromaticum]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acedo | [[Category: Acedo JZ]] | ||
[[Category: Doerksen | [[Category: Doerksen T]] | ||
[[Category: Lohans | [[Category: Lohans CT]] | ||
[[Category: Martin-Visscher | [[Category: Martin-Visscher LA]] | ||
[[Category: McKay | [[Category: McKay RT]] | ||
[[Category: Miskolzie | [[Category: Miskolzie M]] | ||
[[Category: Towle | [[Category: Towle KM]] | ||
[[Category: Vederas | [[Category: Vederas JC]] | ||
Latest revision as of 13:26, 14 June 2023
NMR Solution Structure of the Two-component Bacteriocin CbnXYNMR Solution Structure of the Two-component Bacteriocin CbnXY
Structural highlights
FunctionPublication Abstract from PubMedIn this study, we report that CbnX (33 residues) and CbnY (29 residues) comprise a class IIb (two-component) bacteriocin in Carnobacteria. Individually, CbnX and CbnY are inactive, but together act synergistically to exert a narrow spectrum of activity. The structures of CbnX and CbnY in structure-inducing conditions were determined and strongly resemble other class IIb bacteriocins (i.e., LcnG, PlnEF, PlnJK). CbnX has an extended, amphipathic alpha-helix and a flexible C terminus. CbnY has two alpha-helices (one hydrophobic, one amphipathic) connected by a short loop and a cationic C terminus. CbnX and CbnY do not appear to interact directly and likely require a membrane-bound receptor to facilitate formation of the bacteriocin complex. This is the first class IIb bacteriocin reported for Carnobacteria. Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria.,Acedo JZ, Towle KM, Lohans CT, Miskolzie M, McKay RT, Doerksen TA, Vederas JC, Martin-Visscher LA FEBS Lett. 2017 May;591(10):1349-1359. doi: 10.1002/1873-3468.12648. Epub 2017, Apr 27. PMID:28391617[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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