4b6v: Difference between revisions

No edit summary
No edit summary
Line 1: Line 1:


==The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety==
==The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety==
<StructureSection load='4b6v' size='340' side='right'caption='[[4b6v]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='4b6v' size='340' side='right'caption='[[4b6v]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b6v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B6V FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b6v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B6V FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b6u|4b6u]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b6v OCA], [https://pdbe.org/4b6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b6v RCSB], [https://www.ebi.ac.uk/pdbsum/4b6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b6v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b6v OCA], [https://pdbe.org/4b6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b6v RCSB], [https://www.ebi.ac.uk/pdbsum/4b6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b6v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IF4E3_MOUSE IF4E3_MOUSE]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.<ref>PMID:15153109</ref>
[https://www.uniprot.org/uniprot/IF4E3_MOUSE IF4E3_MOUSE] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.<ref>PMID:15153109</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 26: Line 25:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Baguet, A]]
[[Category: Baguet A]]
[[Category: Borden, K L.B]]
[[Category: Borden KLB]]
[[Category: Culjkovic-Kraljcic, B]]
[[Category: Culjkovic-Kraljcic B]]
[[Category: Kornblatt, J A]]
[[Category: Kornblatt JA]]
[[Category: Osborne, M J]]
[[Category: Osborne MJ]]
[[Category: Volpon, L]]
[[Category: Volpon L]]
[[Category: M7g cap]]
[[Category: Translation]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA