2ldc: Difference between revisions

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OCA

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 ==Solution structure of the estrogen receptor-binding stapled peptide SP1 (Ac-HXILHXLLQDS-NH2)==
-<StructureSection load='2ldc' size='340' side='right'caption='[[2ldc]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2ldc' size='340' side='right'caption='[[2ldc]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ldc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LDC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ldc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LDC FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lda|2lda]], [[2ldd|2ldd]]</div></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ldc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ldc OCA], [https://pdbe.org/2ldc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ldc RCSB], [https://www.ebi.ac.uk/pdbsum/2ldc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ldc ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
+== Function ==
+[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 24: @@
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Bazin, R]]
+[[Category: Bazin R]]
-[[Category: Bent, A]]
+[[Category: Bent A]]
-[[Category: Brown, D]]
+[[Category: Brown D]]
-[[Category: Davies, N]]
+[[Category: Davies N]]
-[[Category: Irving, S]]
+[[Category: Irving S]]
-[[Category: Moore, R]]
+[[Category: Moore R]]
-[[Category: Pannifer, A]]
+[[Category: Pannifer A]]
-[[Category: Phillips, C]]
+[[Category: Phillips C]]
-[[Category: Pickford, A]]
+[[Category: Pickford A]]
-[[Category: Prior, S]]
+[[Category: Prior S]]
-[[Category: Read, C]]
+[[Category: Read C]]
-[[Category: Roberts, L]]
+[[Category: Roberts L]]
-[[Category: Schade, M]]
+[[Category: Schade M]]
-[[Category: Scott, A]]
+[[Category: Scott A]]
-[[Category: Xu, B]]
+[[Category: Xu B]]
-[[Category: De novo protein]]