2byf: Difference between revisions

<StructureSection load='2byf' size='340' side='right'caption='[[2byf]]' scene=''>

<table><tr><td colspan='2'>[[2byf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BYF FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2byf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2byf OCA], [https://pdbe.org/2byf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2byf RCSB], [https://www.ebi.ac.uk/pdbsum/2byf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2byf ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PLCE1_HUMAN PLCE1_HUMAN] Familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis;Familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis. The disease is caused by mutations affecting the gene represented in this entry.

[https://www.uniprot.org/uniprot/PLCE1_HUMAN PLCE1_HUMAN] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.<ref>PMID:11022047</ref> <ref>PMID:11395506</ref> <ref>PMID:11715024</ref> <ref>PMID:11877431</ref> <ref>PMID:12721365</ref> <ref>PMID:16537651</ref> <ref>PMID:17086182</ref>  

[[Category: Homo sapiens]]

[[Category: Bunney TD]]

[[Category: Driscoll PC]]

[[Category: Esposito D]]

[[Category: Gandarillas NL]]

[[Category: Gieschik P]]

[[Category: Harris R]]

[[Category: Josephs MB]]

[[Category: Katan M]]

[[Category: Paterson HF]]

[[Category: Pearl LH]]

[[Category: Rodrigues-Lima F]]

[[Category: Roe SM]]