8ip5: Difference between revisions

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'''Unreleased structure'''


The entry 8ip5 is ON HOLD  until Paper Publication
==Cryo-EM structure of hMRS2-lowEDTA==
 
<StructureSection load='8ip5' size='340' side='right'caption='[[8ip5]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ip5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IP5 FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ip5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ip5 OCA], [https://pdbe.org/8ip5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ip5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ip5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ip5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MRS2_HUMAN MRS2_HUMAN] Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).<ref>PMID:11401429</ref> <ref>PMID:18384665</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li M]]
[[Category: Li Y]]
[[Category: Shen YQ]]
[[Category: Yang X]]

Revision as of 11:20, 14 June 2023

Cryo-EM structure of hMRS2-lowEDTACryo-EM structure of hMRS2-lowEDTA

Structural highlights

8ip5 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MRS2_HUMAN Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).[1] [2]

References

  1. ↑ Zsurka G, Gregán J, Schweyen RJ. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics. 2001 Mar 1;72(2):158-68. PMID:11401429 doi:10.1006/geno.2000.6407
  2. ↑ Piskacek M, Zotova L, Zsurka G, Schweyen RJ. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. J Cell Mol Med. 2009 Apr;13(4):693-700. PMID:18384665 doi:10.1111/j.1582-4934.2008.00328.x

8ip5, resolution 2.50Å

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