8d7k: Difference between revisions

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'''Unreleased structure'''


The entry 8d7k is ON HOLD  until Paper Publication
==Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus==
 
<StructureSection load='8d7k' size='340' side='right'caption='[[8d7k]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8d7k]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D7K FirstGlance]. <br>
Description:  
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d7k OCA], [https://pdbe.org/8d7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d7k RCSB], [https://www.ebi.ac.uk/pdbsum/8d7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d7k ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[https://www.uniprot.org/uniprot/CATG_HUMAN CATG_HUMAN] Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.<ref>PMID:8194606</ref> <ref>PMID:1861080</ref> <ref>PMID:1937776</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus Mu50]]
[[Category: Geisbrecht BV]]
[[Category: Gido CD]]
[[Category: Herdendorf TJ]]

Revision as of 11:17, 14 June 2023

Bifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureusBifunctional Inhibition of Neutrophil Elastase and Cathepsin G by Eap2 from S. aureus

Structural highlights

8d7k is a 12 chain structure with sequence from Homo sapiens and Staphylococcus aureus subsp. aureus Mu50. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CATG_HUMAN Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.[1] [2] [3]

References

  1. ↑ Avril LE, Di Martino-Ferrer M, Pignede G, Seman M, Gauthier F. Identification of the U-937 membrane-associated proteinase interacting with the V3 loop of HIV-1 gp120 as cathepsin G. FEBS Lett. 1994 May 23;345(1):81-6. PMID:8194606
  2. ↑ Maison CM, Villiers CL, Colomb MG. Proteolysis of C3 on U937 cell plasma membranes. Purification of cathepsin G. J Immunol. 1991 Aug 1;147(3):921-6. PMID:1861080
  3. ↑ Wasiluk KR, Skubitz KM, Gray BH. Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. Infect Immun. 1991 Nov;59(11):4193-200. PMID:1937776

8d7k, resolution 3.10Å

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OCA
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