1l2n: Difference between revisions
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'''Smt3 Solution Structure''' | '''Smt3 Solution Structure''' | ||
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[[Category: Liao, X.]] | [[Category: Liao, X.]] | ||
[[Category: Sheng, W.]] | [[Category: Sheng, W.]] | ||
[[Category: | [[Category: Nmr]] | ||
[[Category: | [[Category: Smt3]] | ||
[[Category: | [[Category: Structure]] | ||
[[Category: | [[Category: Ubiquitin-like protein]] | ||
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Revision as of 23:28, 2 May 2008
Smt3 Solution Structure
OverviewOverview
Smt3 belongs to a growing family of ubiquitin-related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell-cycle regulation. Here we report the high-resolution NMR structure of yeast Smt3 in the complex free form. Our comparison of the Smt3 NMR structure with the Smt3 crystal structure in complex with the C-Terminal Ulp1 protease domain revealed large structural differences in the binding surface, which is also involved in the Smt3-Ubc-9 interaction detected by NMR. The structural differences in the region indicate the important functions of conserved residues in less structurally defined sequences.
About this StructureAbout this Structure
1L2N is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions., Sheng W, Liao X, Protein Sci. 2002 Jun;11(6):1482-91. PMID:12021447 Page seeded by OCA on Fri May 2 23:28:25 2008