Igf1 - alec: Difference between revisions
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== Overview == | == Overview == | ||
<StructureSection load='1gzy' size='340' side='right' caption='Human insulin-like growth factor I complex with dodecyldimethylammonio-propanesulfonate (PDB code [[1gzy]])' scene=''> | <StructureSection load='1gzy' size='340' side='right' caption='Human insulin-like growth factor I complex with dodecyldimethylammonio-propanesulfonate (PDB code [[1gzy]])' scene=''> | ||
The protein '''Insulin-like Growth Factor 1 (IGF-1)''' is a liver protein that shows many similarities to Insulin. The two molecules have around sixty percent similarities in their structures, and are released under similar circumstances into the bloodstream. IGF-1 acts as the main growth factor to insulin, acting as the nutrition for cells. The similarities between the two molecules allows for easy transportation of IGF-1 through the bloodstream. As insulin is released into the blood upon hyperglycemic conditions, IGF-1 is released upon excess protein intake and will transport the proteins to cells where it can be used for growth. IGF-1 release can also be stimulated by secretion of Growth Hormone, which induces the protein to deliver nutrients to cells. This process occurs extensively throughout puberty of children. Additionally, after puberty, IGF-1 can be regulated by the release of GH but not to the level of that during puberty and can regularly be secreted without GH stimulus. There have been recent studies showing the biological necessity for IGF-1, as well as the costs of having low levels of this protein which range from reduced cell growth to dysfunctions of particular cells. <ref name = 'Clemmons'> PMID: 22682639 </ref> | The protein '''Insulin-like Growth Factor 1 ([[IGF-1]])''' is a liver protein that shows many similarities to Insulin. The two molecules have around sixty percent similarities in their structures, and are released under similar circumstances into the bloodstream. IGF-1 acts as the main growth factor to insulin, acting as the nutrition for cells. The similarities between the two molecules allows for easy transportation of IGF-1 through the bloodstream. As insulin is released into the blood upon hyperglycemic conditions, IGF-1 is released upon excess protein intake and will transport the proteins to cells where it can be used for growth. IGF-1 release can also be stimulated by secretion of Growth Hormone, which induces the protein to deliver nutrients to cells. This process occurs extensively throughout puberty of children. Additionally, after puberty, IGF-1 can be regulated by the release of GH but not to the level of that during puberty and can regularly be secreted without GH stimulus. There have been recent studies showing the biological necessity for IGF-1, as well as the costs of having low levels of this protein which range from reduced cell growth to dysfunctions of particular cells. <ref name = 'Clemmons'> PMID: 22682639 </ref> | ||
See also [[Insulin-like growth factor]]. | See also [[Insulin-like growth factor]]. | ||