7ynk: Difference between revisions

Revision as of 08:36, 31 May 2023

Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformationStructure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation

Structural highlights

7ynk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SC5A2_HUMAN Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.

Function

SC5A2_HUMAN Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]^[1] ^[2] ^[3]

References

↑ Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan;300(1):C14-21. doi:, 10.1152/ajpcell.00388.2010. Epub 2010 Oct 27. PMID:20980548 doi:http://dx.doi.org/10.1152/ajpcell.00388.2010
↑ Coady MJ, Wallendorff B, Lapointe JY. Characterization of the transport activity of SGLT2/MAP17, the renal low-affinity Na(+)-glucose cotransporter. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F467-F474. PMID:28592437 doi:10.1152/ajprenal.00628.2016
↑ Niu Y, Liu R, Guan C, Zhang Y, Chen Z, Hoerer S, Nar H, Chen L. Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. Nature. 2022 Jan;601(7892):280-284. PMID:34880493 doi:10.1038/s41586-021-04212-9

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OCA

[1] Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan;300(1):C14-21. doi:, 10.1152/ajpcell.00388.2010. Epub 2010 Oct 27. PMID:20980548 doi:http://dx.doi.org/10.1152/ajpcell.00388.2010

[2] Coady MJ, Wallendorff B, Lapointe JY. Characterization of the transport activity of SGLT2/MAP17, the renal low-affinity Na(+)-glucose cotransporter. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F467-F474. PMID:28592437 doi:10.1152/ajprenal.00628.2016

[3] Niu Y, Liu R, Guan C, Zhang Y, Chen Z, Hoerer S, Nar H, Chen L. Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. Nature. 2022 Jan;601(7892):280-284. PMID:34880493 doi:10.1038/s41586-021-04212-9

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ynk is ON HOLD  until Paper Publication
+==Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation==
+<StructureSection load='7ynk' size='340' side='right'caption='[[7ynk]], [[Resolution|resolution]] 3.48&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ynk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YNK FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ynk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ynk OCA], [https://pdbe.org/7ynk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ynk RCSB], [https://www.ebi.ac.uk/pdbsum/7ynk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ynk ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen L]]
+[[Category: Niu Y]]

7ynk: Difference between revisions

Revision as of 08:36, 31 May 2023

Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformationStructure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation

Structural highlights

Disease

Function

References

Contents

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7ynk: Difference between revisions

Revision as of 08:36, 31 May 2023

Structure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformationStructure of human SGLT2-MAP17 complex in the apo state in the inward-facing conformation

Structural highlights

Disease

Function

References

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