5afk: Difference between revisions
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<StructureSection load='5afk' size='340' side='right'caption='[[5afk]], [[Resolution|resolution]] 2.38Å' scene=''> | <StructureSection load='5afk' size='340' side='right'caption='[[5afk]], [[Resolution|resolution]] 2.38Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5afk]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5afk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lymnaea_stagnalis Lymnaea stagnalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AFK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5VU:N-(2,4-DIFLUOROPHENYL)PYRROLIDINE-1-CARBOXAMIDE'>5VU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L0B:ALPHA-LOBELINE'>L0B</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VU:N-(2,4-DIFLUOROPHENYL)PYRROLIDINE-1-CARBOXAMIDE'>5VU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L0B:ALPHA-LOBELINE'>L0B</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5afk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afk OCA], [https://pdbe.org/5afk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5afk RCSB], [https://www.ebi.ac.uk/pdbsum/5afk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5afk ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] 15q13.3 microdeletion syndrome. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACHP_LYMST ACHP_LYMST] Binds to acetylcholine. Modulates neuronal synaptic transmission.[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Atack | [[Category: Lymnaea stagnalis]] | ||
[[Category: Bertrand | [[Category: Atack J]] | ||
[[Category: Danielson | [[Category: Bertrand D]] | ||
[[Category: Debaveye | [[Category: Danielson UH]] | ||
[[Category: Farinha | [[Category: Debaveye S]] | ||
[[Category: Gossas | [[Category: Farinha A]] | ||
[[Category: Kemp | [[Category: Gossas T]] | ||
[[Category: Spurny | [[Category: Kemp J]] | ||
[[Category: Tresadern | [[Category: Spurny R]] | ||
[[Category: Ulens | [[Category: Tresadern G]] | ||
[[Category: Veys | [[Category: Ulens C]] | ||
[[Category: Vos | [[Category: Veys K]] | ||
[[Category: Vos A]] | |||