5acl: Difference between revisions

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OCA

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 <StructureSection load='5acl' size='340' side='right'caption='[[5acl]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5acl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ACL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ACL FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5acl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ACL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ACL FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAS:2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC+ACID'>SAS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAS:2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC+ACID'>SAS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5acm|5acm]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5acl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5acl OCA], [https://pdbe.org/5acl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5acl RCSB], [https://www.ebi.ac.uk/pdbsum/5acl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5acl ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5acl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5acl OCA], [http://pdbe.org/5acl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5acl RCSB], [http://www.ebi.ac.uk/pdbsum/5acl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5acl ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LV208_HUMAN LV208_HUMAN] V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref> <ref>PMID:24600447</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Brumshtein, B]]
+[[Category: Brumshtein B]]
-[[Category: Cascio, D]]
+[[Category: Cascio D]]
-[[Category: Eisenberg, D S]]
+[[Category: Eisenberg DS]]
-[[Category: Esswein, S R]]
+[[Category: Esswein SR]]
-[[Category: Ly, A T]]
+[[Category: Ly AT]]
-[[Category: Phillips, M L]]
+[[Category: Phillips ML]]
-[[Category: Salwinski, L]]
+[[Category: Salwinski L]]
-[[Category: Sawaya, M R]]
+[[Category: Sawaya MR]]
-[[Category: Immune system]]
-[[Category: Immunoglobulin variable domain]]
-[[Category: Mcg]]
-[[Category: Methylene blue]]