8seo: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 8seo is ON HOLD  until Paper Publication
+==Cryo-EM Structure of RyR1 + ATP-gamma-S==
+<StructureSection load='8seo' size='340' side='right'caption='[[8seo]], [[Resolution|resolution]] 3.92&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8seo]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SEO FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8seo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8seo OCA], [https://pdbe.org/8seo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8seo RCSB], [https://www.ebi.ac.uk/pdbsum/8seo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8seo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Berezuk AM]]
+[[Category: Cholak S]]
+[[Category: Haji-Ghassemi O]]
+[[Category: Saville JW]]
+[[Category: Subramaniam S]]
+[[Category: Tuttle KS]]
+[[Category: Van Petegem F]]
+[[Category: Zhu X]]