4zy3: Difference between revisions

<table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [https://pdbe.org/4zy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zy3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>  

[[Category: Mus musculus]]

[[Category: Fukutomi T]]

[[Category: Iso T]]

[[Category: Komatsu M]]

[[Category: Mizushima T]]

[[Category: Suzuki T]]

[[Category: Takagi K]]

[[Category: Yamamoto M]]