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==Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)==
==Crystal structure of the heterocomplex between coil 2B domains of human intermediate filament proteins keratin 1 (KRT1) and keratin 10 (KRT10)==
<StructureSection load='4zry' size='340' side='right' caption='[[4zry]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4zry' size='340' side='right'caption='[[4zry]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZRY FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KRT10, KPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), KRT1, KRTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [https://pdbe.org/4zry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [https://www.ebi.ac.uk/pdbsum/4zry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zry OCA], [http://pdbe.org/4zry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zry RCSB], [http://www.ebi.ac.uk/pdbsum/4zry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zry ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] Epidermolytic palmoplantar keratoderma;Ichthyosis hystrix of Curth-Macklin;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis;Keratosis palmoplantaris striata. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/K2C1_HUMAN K2C1_HUMAN]] May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.<ref>PMID:17956333</ref> <ref>PMID:21544310</ref> 
[https://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zry" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zry" style="background-color:#fffaf0;"></div>
==See Also==
*[[Keratins|Keratins]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Bunick, C G]]
[[Category: Large Structures]]
[[Category: Steitz, T A]]
[[Category: Bunick CG]]
[[Category: Coiled-coil]]
[[Category: Steitz TA]]
[[Category: Epidermis]]
[[Category: Helix]]
[[Category: Intermediate filament]]
[[Category: Keratin]]
[[Category: Protein fibril]]
[[Category: Protein-protein complex]]
[[Category: Skin]]

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