Hepatocyte growth factor receptor: Difference between revisions

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Juliette Personius, Michal Harel, Alexander Berchansky

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 ==Introduction==
-The '''Hepatocyte Growth Factor Receptor''' plays a large role in embryonic development, as its activation leads to events such as cell growth, motility and invasion. This receptor is a Tyrosine Kinase, and is one of the most well studied [[Receptor tyrosine kinases|RTKs]], as mutations in the c-met proto-oncogene can lead to the formation of tumors. The ligand for this receptor is Hepatocyte growth factor/scatter factor (HGF/SF), and upon binding of this ligand, the receptor becomes auto phosphorylated, causing downstream signaling events such as cell growth. <ref>PMID: 14559966</ref> C-Met is an αβ heterodimer with extracellular and intracellular domains. These two domains are disulfide linked together. <ref>PMID: 14559966</ref> This particular structure is one of a mutated hepatocyte growth factor tyrosine kinase domain, which is part of the intracellular β subunit.<ref>http://en.wikipedia.org/wiki/C-Met</ref>. See also [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]].
+The '''Hepatocyte Growth Factor Receptor''' or '''tyrosine-protein kinase Met''' or '''c-Met'''  plays a large role in embryonic development, as its activation leads to events such as cell growth, motility and invasion. This receptor is a Tyrosine Kinase, and is one of the most well studied [[Receptor tyrosine kinases|RTKs]], as mutations in the c-met proto-oncogene can lead to the formation of tumors. The ligand for this receptor is Hepatocyte growth factor/scatter factor (HGF/SF), and upon binding of this ligand, the receptor becomes auto phosphorylated, causing downstream signaling events such as cell growth. <ref>PMID: 14559966</ref> C-Met is an αβ heterodimer with extracellular and intracellular domains. These two domains are disulfide linked together. <ref>PMID: 14559966</ref> This particular structure is one of a mutated hepatocyte growth factor tyrosine kinase domain, which is part of the intracellular β subunit.<ref>http://en.wikipedia.org/wiki/C-Met</ref>. See also [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]].
 ==Structure==